Procaryotic and eucaryotic cells Procaryotic cells & eukaryotic cells are the two types of cells that exist on Earth. There are several differences between the two, but the biggest distinction between them is that eukaryotic cells have a distinct nucleus containing the cell's genetic material, while prokaryotic cells don't have a nucleus and have free-floating genetic material instead. From prokaryotic cells to eukaryotic cells All living things can be divided into three basic domains: Bacteria, Archaea and Eukarya. The primarily single-celled organisms found in the Bacteria and Archaea domains are known as prokaryotes. These organisms are made of prokaryotic cells — the smallest, simplest and most ancient cells. Organisms in the Eukarya domain are made of the more complex eukaryotic cells. These organisms, called eukaryotes, can be unicellular or multicellular & include animals, plants, fungi & protists. Many people are unclear on whether yeasts ...